Description

Indication/s

  • Constipation: regulation of the physiological rhythm of the colon
  • Where a soft stool is considered of medical benefit (hemorrhoids, post colonic/anal surgery)
  • Hepatic Encephalopathy (HE): treatment and prevention of hepatic coma or precoma (adults)
  • For bowel cleansing in preparation for colonoscopy (adults)
  • As a prebiotic, helps create and maintain a healthy intestinal balance and stimulates intestinal absorption of minerals like calcium and magnesium (adults)

Contraindication/s

  • Hypersensitivity to the active substance or ingredients
  • Galactosemia
  • Gastrointestinal obstruction, digestive perforation, or risk thereof
  • Should not be used for bowel cleansing in unconscious patients or those with aspiration risk, severe dehydration, or swallowing issues

Storage Condition

Store at temperatures not exceeding 25°C. Protect from light.

Dosage and Administration

Adults and Adolescents (≥14 years):

  • Starting dose: 15–45 mL per day
  • Maintenance dose: 15–30 mL per day

Children (7–14 years):

  • Starting dose: 15 mL per day
  • Maintenance dose: 10–15 mL per day

Children (1–6 years):

  • Usual dose: 5–10 mL per day

Infants (<1 year):

  • Usual dose: Up to 5 mL per day

Special Instructions

  • Administer with care to lactose-intolerant patients
  • Usual constipation doses are safe for diabetics; HE doses may need caution
  • Chronic misuse can cause diarrhea and electrolyte imbalance
  • Contains lactose, galactose, and fructose — avoid in hereditary intolerance cases
  • Refer to the patient leaflet for complete prescribing information

Mechanism of Action

  • Draws water into the colon to soften stool and promote bowel movement
  • Reduces blood ammonia by converting NH₃ to NH₄⁺ in the colon
  • Metabolized by gut bacteria into SCFAs to lower pH and enhance laxative effect

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